Recent Advances in Enantioselective Direct C–H Addition to Carbonyls and Michael Acceptors

Enantioselective C-H addition is one of the most straightforward and efficient approaches towards synthesis optically active molecules from readily available arenes. The significant feature these reactions that nucleophilic aryl metal species generated catalytically in situ via C–H bond activation. These typically proceed without requirement either strongly basic or acidic conditions, thus with good functional group compatibility. In this review, recent progress on transition-metal-catalyzed enantioselective direct to polar unsaturated bonds summarized. intramolecular additions carbonyls enabled by Ir(I) Rh(III) catalyst provided an access chiral alcohol scaffolds high efficiency. Planar 1,2-substituted ferrocenes were afforded acrylates Ir/chiral diene catalyst. addition, asymmetric hydroarylation Michael acceptors including acrylates, ?, ?-unsaturated esters nitroolefins also described. Moreover, conjugate aromatic benzylic ketones catalyzed Cp*M(III)/chiral acid hybrid (M = Rh, Co) presented. a structurally diverse valuable fragments. Meanwhile, reaction mechanisms are introduced. Recent progresses Ir, Rh Co provide